What is the purpose of the Hevel lab?

So.. as as significant blog post that you might be able to respond to, I will share a little background that hopefully is pretty clear on what the Hevel lab over in Widtsoe is all about.

The human body is like a microscopic country. In order to properly function, all the different locations must be able to communicate both globally and locally. Locally cells use signaling pathways to detect and to respond to signals from the body. Passing along a signal can be done chemically in many different ways; one way is by enzymatically adding a small molecule to a protein to alter its function. Many significant physiological pathways, such as DNA repair, signal transduction, and RNA processing are regulated by one such small modification known as arginine methylation, where protein arginine methyltransferases (PRMTs) transfer a small methyl group onto an arginine residue. This transfer can be done three ways; a single CH₃ can be added to form monomethylarginine (MMA), two CH₃ groups can be added to different nitrogens to form symmetric dimethylarginine (SDMA), or two CH₃ groups can be added to the same nitrogen to form asymmetric dimethylarginine (ADMA). Which product is formed has been observed to be important for either activating or repressing the ability of a cell to use certain pieces of its DNA. Understanding how PRMT1 targets its substrate(s) lends vital information for drug development, often based on block the enzymes ability to perform a key step in the pathway of choice.

Any questions or comments I can answer?